袁正偉，男，1966年11月生，醫(yī)學博士，博士生導師，國家衛(wèi)健委小兒先天畸形重點實驗室主任，中國醫(yī)科大學附屬盛京醫(yī)院國家兒童區(qū)域醫(yī)療中心學術帶頭人，中華醫(yī)學會小兒外科分會委員，遼寧省醫(yī)學會小兒外科分會副主委，遼寧省醫(yī)學會理事，遼寧省細胞學會干細胞與再生專業(yè)委員會副主任委員，遼寧省科技創(chuàng)新領軍人才，遼寧省優(yōu)秀專家，遼寧省高校創(chuàng)新團隊負責人。擔任中華小兒外科雜志編委，Neuroproteomics副主編，F(xiàn)rontiers in cell and developmental biology副主編，Journal of Integrated OMICS副主編，發(fā)育醫(yī)學雜志副主編。榮獲2001年日本武藤醫(yī)學獎，2002年遼寧省優(yōu)秀中青年骨干教師，2006年中國醫(yī)科大學科學研究與技術開發(fā)特殊貢獻獎勵津貼，2007年中國醫(yī)科大學優(yōu)秀專家，2007年遼寧省百千萬人才工程百人層次，2014年遼寧省高校創(chuàng)新團隊帶頭人，2018年遼寧省優(yōu)秀專家，2019年遼寧省“興遼英才計劃”科技創(chuàng)新領軍人才，2021年被評為二級教授。作為第一負責人先后獲得9項國家自然科學基金，2項國家重點專項課題，1項國家重點專項子課題，1項973子課題，獲得科研經(jīng)費總計2000余萬元。在國外核心期刊發(fā)表論文252篇，其中SCI收錄154篇（第一或通訊作者66篇，其中中科院分區(qū)1區(qū)8篇、2區(qū)28篇）。作為第一完成人科研成果獲得遼寧省科技進步一等獎1項，中國醫(yī)院協(xié)會醫(yī)院科技創(chuàng)新三等獎1項；作為第二完成人獲得國家科技進步二等獎1項，遼寧省科技進步一等獎1項，教育部科技進步一等獎1項，遼寧省科技進步二等獎1項，三等獎2項。獲得發(fā)明專利6項，其中專利成果轉化1項，轉化金額100萬元。指導研究生62人，其中博士研究生36人，碩士研究生26人，培養(yǎng)的博士研究生榮獲遼寧省優(yōu)秀學位論文。

教育經(jīng)歷：

1983年-1989年，畢業(yè)于中國醫(yī)科大學醫(yī)學系，醫(yī)學學士學位。

1989-1992中國醫(yī)科大學附屬盛京醫(yī)院醫(yī)學碩士學位小兒外科

1994-1997中國醫(yī)科大學附屬盛京醫(yī)院醫(yī)學博士學位小兒外科

工作經(jīng)歷：

1992-2003中國醫(yī)科大學附屬盛京醫(yī)院副教授小兒外科。

1999-2002香港大學RA基礎研究。

2003-至今中國醫(yī)科大學附屬盛京醫(yī)院教授,副主任小兒外科。

學術兼職及社會任職：

1. 中華醫(yī)學會小兒外科分會委員。

2. 中華醫(yī)學會小兒外科分會中青年委員會副主任委員。

3. 遼寧省醫(yī)學會理事。

4. 遼寧省細胞學會干細胞與再生專業(yè)委員會副主任委員。

5. 遼寧省醫(yī)學會小兒外科分會委員,中華小兒外科雜志編委。

6. Journal of Integrated OMICS副主編。

7. Neuroproteomics副主編。

8. 發(fā)育醫(yī)學雜志副主編。 

主講課程：

資料更新中…… 

培養(yǎng)研究生情況：

指導研究生62人，其中博士研究生36人，碩士研究生26人，培養(yǎng)的博士研究生榮獲遼寧省優(yōu)秀學位論文。

研究方向：

1. 小兒先天畸形胚胎發(fā)育及其遺傳基因篩查。

2. 感染因素所致先天畸形的機理研究。

3. 遺傳病分子遺傳學研究。

承擔科研項目情況：

先后獲得國家自然基金6項，參加973項目1項，獲得科研經(jīng)費500余萬元。  

1、兒童結構出生缺陷防控和救助體系的構建及示范應用，批準號：2021YFC2701003，科技部，袁正偉，658萬元，2021.12-2024.11

2、重大出生缺陷中基因突變致病性的系統(tǒng)識別及其非經(jīng)典致病機制解析，批準號：2021YFC2701104，科技部，袁正偉，150萬元，2021.12-2024.11

3、神經(jīng)管畸形發(fā)生的關鍵基因篩選、驗證及交互調(diào)控新機制研究，批準號：82171649，國家自然科學基金，袁正偉，55萬元，2022.1-2025.12

4、宮內(nèi)羊膜腔注射移植的干細 胞向神經(jīng)管畸形病變部位定 向遷移的分子機制研究及其 遠期神經(jīng)功能恢復的效果評價，批準號：81871219，國家自然科學基金，袁正偉，57萬元，2019.1-2022.12

5、利用新篩選的血清分子標志物構建神經(jīng)管畸形產(chǎn)前診斷模型及其機制研究，81671469，國家自然科學基金，袁正偉，57萬元，2017.1-2020.1

6、出生缺陷的預測預警及早期診斷的優(yōu)化方案，批準號：2016YFC1000505，科技部，袁正偉，480萬元，2016.7-2021.6

7、血漿銅藍蛋白作為神經(jīng)管畸形胚胎早期診斷分子標志物的價值及其機制探討，批準號：81370717，國家863計劃子項目，袁正偉，70萬元，2014.1.-2017.12

8、代謝物失衡和信號通路異常致出生缺陷的分子機理，批準號：2013CB945402，973項目子課題，袁正偉，100萬元，2013.1-2015.12

9、骨髓間充質(zhì)干細胞移植聯(lián)合RNAi沉默CRMP4對先天性脊椎裂胚胎早期治療，批準號：39770763，國家自然科學基金，袁正偉，62萬元，2012.1-2015.12

10、利用具有不同分化特性的骨髓間充質(zhì)干細胞單細胞克隆構建組織工程支架進行先天性顯性脊柱裂治療的研究，批準號：81070538  國家自然科學基金，袁正偉，40萬元，2011.1-2013.12

11、干細胞移植在胚胎組織內(nèi)遷移、分化規(guī)律及其對隱性脊椎裂治療效果研究，批準號：30872705，國家自然科學基金，袁正偉，35萬元，2009.1-2011.12

12、先天性脊椎裂、先天性肛門直腸畸形和先天性馬蹄內(nèi)翻足的共同胚胎發(fā)生規(guī)律與早期診斷研究，批準號：30571934，國家自然科學基金，袁正偉，26，2006.1-2008.12

13、骨髓間充質(zhì)干細胞移植聯(lián)合14-3-3基因轉染治療先天性脊椎裂的新方法研究，教育部博士點基金，12萬元，2013.01-2015.12。

14、先天畸形胚胎發(fā)生機制與早期診斷、預防新策略，遼寧省教育廳創(chuàng)新團隊，100萬元，2014.01-2016.12。

15、小兒排尿功能障礙的診斷與治療小兒外科術后康復與功能重建小兒神經(jīng)管畸形的基礎與臨床研究。

科研成果：

1. 獲遼寧省科技進步獎多項。編寫《小兒排尿功能障礙的診斷與治療》一書。

2. 從事的課題建立了神經(jīng)電生理、多導直腸肛管向量測壓、X線和同位素動態(tài)排便造影等手段系統(tǒng)研究肛門直腸畸形術后排便功能障礙發(fā)生的病理機制，提出排便功能障礙的5種病理類型，并在國內(nèi)外首次創(chuàng)造性地設計有針對性的生物反饋治療方法，排便功能評分平均增加2分以上，成為有效治療肛門直腸畸形術后排便功能異常的重要手段。這部分內(nèi)容后來也成為2007年申報國家科技進步獎二等獎的重要創(chuàng)新點之一。 

3. 率領課題團隊取得了輝煌的成果：國家科技進步獎二等獎1項，教育部科技進步獎一等獎1項，遼寧省科技進步獎一等獎1項，二等獎1項，三等獎2項。在“十五”期間共獲得各種科研基金資助30項，其中包括參加“973”工程項目1項，國家自然科學基金13項，省部級重點課題5項等，總資助經(jīng)費550余萬元。在國內(nèi)外核心期刊共發(fā)表論著130余篇，其中有57篇在國外雜志發(fā)表并被SCI收錄，參編相關專著5部。研究成果在2001年榮獲日本武藤醫(yī)學獎。

認定成果 

1 先天性肛門直腸畸形基礎與臨床研究 王維林;袁正偉;張志波;白玉作;李龍;李正;王練英;王常林;馮國和;王偉;賈慧敏;劉穎;劉瑩 中國醫(yī)科大學盛京醫(yī)院 2005

2 先天性肛門直腸畸形的基礎與臨床研究 王維林;袁正偉;張志波;白玉作;李龍;李正;王練英;王常林;王偉;賈慧敏;劉穎;劉瑩 中國醫(yī)科大學盛京醫(yī)院 2005

3 小兒肛門直腸畸形術后生物反饋治療及遠期生活質(zhì)量評估的研究 王維林;白玉作;袁正偉;王偉;陳輝;李志祥;肖福大;黃英;郝晶 中國醫(yī)科大學盛京醫(yī)院 2001

論文專著：

發(fā)表論文100余篇，其中SCI收錄論文50余篇。

編寫《小兒排尿功能障礙的診斷與治療》一書。

代表性英文論文： 

[1]Kong, Linghui; Chu, Guoming; Ma, Wei; Liang, Jiajian; Liu, Dan; Liu, Qiushi; Wei, Xiaowei; Jia, Shanshan; Gu, Hui; He, Yiwen; Luo, Wenting; Cao, Songying; Zhou, Xiaomeng; He, Rong*; Yuan, Zhengwei*.Mutations in VWA8 cause autosomal-dominant retinitis pigmentosa via aberrant mitophagy activation.Journal of Medical Genetics, 2023. IF=5.941，1區(qū)

[2]Huang, Wanqi; Fu, Jialin; Yuan, Zhengwei*; Gu, Hui*.Impact of prenatal exposure to metallic elements on neural tube defects: Insights from human investigations.Ecotoxicology and Environmental Safety, 2023, 255: 114815. IF=7.129，1區(qū)

[3]Wei, Xiaowei; Ma, Wei; Gu, Hui; Liu, Dan; Luo, Wenting; Cao, Songying; Jia, Shanshan; Huang, Tianchu; He, Yiwen; Bai, Yuzuo; Wang, Weilin; Yuan, Zhengwei*.Intra-amniotic mesenchymal stem cell therapy improves the amniotic fluid microenvironment in rat spina bifida aperta fetuses.Cell Proliferation, 2023, 56(2).e13354. IF=8.755，1區(qū)

[4]Yin, Jiali; Shi, Dongxin; Sun, Yan; Zhu, Peiyao; Zhao, Yiping; Xu, Xuegang; Chen, Hongduo; Wu, Yan*; Yuan, Zhengwei*; Gao, Xing-Hua*.IRF7 and CTSS are pivotal for cutaneous wound healing and may serve as therapeutic targets.Signal Transduction and Targeted Therapy, 2023, 8(1): 322. 

[5]Chen, Lizhu; Xiu, Yun; Wu, Qijun; Wang, Yu; Zhang, Yixin; Xue, Jia; Wang, Qinbo; Yuan, Zhengwei*.Maternal serum Lamin A is a potential biomarker that can predict adverse pregnancy outcomes.EBioMedicine, 2022, 77: 103932.. IF=11.205，1區(qū)

[6]Zhao, Duan; Liu, Yusi; Jia, Shanshan; He, Yiwen; Wei, Xiaowei; Liu, Dan; Ma, Wei; Luo, Wenting; Gu, Hui*; Yuan, Zhengwei*.Influence of maternal obesity on the multi-omics profiles of the maternal body, gestational tissue, and offspring.Biomedicine & Pharmacotherapy, 2022, 151: 113103.. IF=7.419，1區(qū)

[7]Li SY, Wang CY, Wei XG, Tang XB, Yuan ZW, Bai YZ. CircJag1 promotes apoptosis of ethylene thiourea-exposed anorectal malformations through sponging miR-137-3p by regulating Sox9 and suppressing Wnt/β-catenin pathway during the hindgut development of rat embryos. Cell Biol Toxicol. 2022 Aug 5. doi: 10.1007/s10565-022-09750-0. Epub ahead of print. IF=6.819，1區(qū)

[8]Liu P, Li Y, Wang W, Bai Y, Jia H, Yuan Z, Yang Z. Role and mechanisms of the NF-ĸB signaling pathway in various developmental processes. Biomed Pharmacother. 2022 Sep;153:113513. IF=7.419，1區(qū)

[9]Jia, Shanshan; Zhang, Qiang; Wang, Yu; Wei, Xiaowei; Gu, Hui; Liu, Dan; Ma, Wei; He, Yiwen; Luo, Wenting; Yuan, Zhengwei*.Identification by RNA-Seq of let-7 clusters as prenatal biomarkers for nonsyndromic cleft lip with palate.Annals of the New York Academy of Sciences, 2022, 1516(1): 234-246.

[10]Wang, Yanfu; Ma, Ling; Jia, Shanshan; Liu, Dan; Gu, Hui; Wei, Xiaowei; Ma, Wei; Luo, Wenting; Bai, Yuzuo; Wang, Weilin; Yuan, Zhengwei*.Serum exosomal coronin 1A and dynamin 2 as neural tube defect biomarkers.Journal of Molecular Medicine-JMM, 2022, 100(9): 1307-1319.

[11]Ma, Wei; Wei, Xiaowei; Gu, Hui; Liu, Dan; Luo, Wenting; Cao, Songying; Jia, Shanshan; He, Yiwen; Chen, Lizhu; Bai, Yuzuo; Yuan, Zhengwei*.Intra-amniotic transplantation of brain-derived neurotrophic factor-modified mesenchymal stem cells treatment for rat fetuses with spina bifida aperta.Stem Cell Research & Therapy, 2022, 13(1): 413.

[12]Wang, Yu; Zhang, Qixin; Yin, Chenghuan; Chen, Lizhu; Yang, Zeyu; Jia, Shanshan; Sun, Xue; Bai, Yuzuo; Han, Fangfang*; Yuan, Zhengwei*.Automated prediction of early spontaneous miscarriage based on the analyzing ultrasonographic gestational sac imaging by the convolutional neural network: a case-control and cohort study.BMC Pregnancy and Childbirth, 2022, 22(1): 621.

[13]Li, Shimeng; Wang, Qinbo; Luo, Wenting; Jia, Shanshan; Liu, Dan; Ma, Wei; Gu, Hui; Wei, Xiaowei; He, Yiwen; Cao, Songying; Yuan, Zhengwei*.Relationship between maternal heavy metal exposure and congenital heart defects: a systematic review and meta-analysis.Environmental Science and Pollution Research, 2022, 29(37): 55348-55366.

[14]Luan, Cai-Xia; Xie, Wei-Dong; Liu, Dan; Li, Wei*; Yuan, Zheng-Wei*.Candidate Circulating Biomarkers of Spontaneous Miscarriage After IVF-ET Identified via Coupling Machine Learning and Serum Lipidomics Profiling.Reproductive Sciences, 2022, 29(3): 750-760.

[15]Ma, Ling; Wei, Xiaowei; Ma, Wei; Liu, Yusi; Wang, Yanfu; He, Yiwen; Jia, Shanshan; Wang, Yu; Luo, Wenting; Liu, Dan; Huang, Tianchu; Yan, Jiayu; Gu, Hui; Bai, Yuzuo; Yuan, Zhengwei*.Neural Stem Cell-Derived Exosomal Netrin1 Contributes to Neuron Differentiation of Mesenchymal Stem Cells in Therapy of Spinal Bifida Aperta.Stem Cells Translational Medicine, 2022.

[16]Huang W, Huang T, Liu Y, Fu J, Wei X, Liu D, Ma W, Gu H, Yuan Z. Nuclear factor I-C disrupts cellular homeostasis between autophagy and apoptosis via miR-200b-Ambra1 in neural tube defects. Cell Death Dis. Cell Death Dis. 2021 Dec 20;13(1):17. IF=9.696，1區(qū)

[17]Jia, Shanshan; Zhang, Qiang; Wang, Yu; Wang, Yanfu; Liu, Dan; He, Yiwen; Wei, Xiaowei; Gu, Hui; Ma, Wei; Luo, Wenting; Yuan, Zhengwei*.PIWI-interacting RNA sequencing profiles in maternal plasma-derived exosomes reveal novel non-invasive prenatal biomarkers for the early diagnosis of nonsyndromic cleft lip and palate.EBioMedicine, 2021, 65: 103253. IF=8.143，1區(qū)

[18]Huang, Jieting; Zhao, Qi; Wei, Xiaowei; Ma, Wei; Luo, Wenting; Gu, Hui; Liu, Dan; He, Yiwen; Huang, Tianchu; Liu, Yusi; Wang, Chenfei; Yuan, Zhengwei*.miR-351-3p promotes rat amniotic fluid-derived mesenchymal stromal cell proliferation via targeting the coding sequence of Abca4.Stem Cells, 2021, 39(9): 1192-1206.

[19]Zhao, Lu; Liu, Dan; Ma, Wei; Gu, Hui; Wei, Xiaowei; Luo, Wenting; Yuan, Zhengwei*.Bhlhe40/Sirt1 Axis-Regulated Mitophagy Is Implicated in All-Trans Retinoic Acid-Induced Spina Bifida Aperta.Frontiers in Cell and Developmental Biology, 2021, 9: 644346.

[20]Zhang, Siwen; Chang, Qiyuan; Li, Pingping; Tong, Xiaoyu; Feng, Yi; Hao, Xinyao; Zhang, Xudong; Yuan, Zhengwei; Tan, Jichun*.Concentrated small extracellular vesicles from menstrual blood-derived stromal cells improve intrauterine adhesion, a pre-clinical study in a rat model.Nanoscale, 2021, 13(15): 7334-7347.

[21]Li, Zijian; Feng, Juan*; Yuan, Zhengwei*.Key Modules and Hub Genes Identified by Coexpression Network Analysis for Revealing Novel Biomarkers for Spina Bifida.Frontiers in Genetics, 2020, 11: 583316.

[22]Ma, Wei; Wei, Xiaowei; Gu, Hui; Liu, Dan; Luo, Wenting; An, Dong; Bai, Yuzuo; Yuan, Zhengwei*.Therapeutic potential of adenovirus-encoding brain-derived neurotrophic factor for spina bifida aperta by intra-amniotic delivery in a rat model.Gene Therapy, 2020, 27(12): 567-578.

[23]Huang, Jieting; Ma, Wei; Wei, Xiaowei; Yuan, Zhengwei*.Amniotic fluid mesenchymal stromal cells from early stages of embryonic development have higher self-renewal potential.In Vitro Cellular & Developmental Biology-Animal, 2020, 56(9): 701-714.

[24]Dong, Naixuan; Gu, Hui; Liu, Dan; Wei, Xiaowei; Ma, Wei; Ma, Ling; Liu, Yusi; Wang, Yanfu; Jia, Shanshan; Huang, Jieting; Wang, Chenfei; He, Xuan; Huang, Tianchu; He, Yiwen; Zhang, Qiang; An, Dong; Bai, Yuzuo; Yuan, Zhengwei*.Complement factors and alpha-fetoprotein as biomarkers for noninvasive prenatal diagnosis of neural tube defects.Annals of the New York Academy of Sciences, 2020, 1478(1): 75-91.

[25]Liu, Yu-si; Gu, Hui*; Huang, Tian-chu; Wei, Xiao-wei; Ma, Wei; Liu, Dan; He, Yi-wen; Luo, Wen-ting; Huang, Jie-ting; Zhao, Duan; Jia, Shan-shan; Wang, Fang; Zhang, Ting; Bai, Yu-zuo; Wang, Wei-lin; Yuan, Zheng-wei*.miR-322 treatment rescues cell apoptosis and neural tube defect formation through silencing NADPH oxidase 4.CNS Neuroscience & Therapeutics, 2020, 26(9): 902-912.

[26]Huang, Jieting; Wei, Xiaowei; Ma, Wei; Yuan, Zhengwei*.The miR-532-3p/Chrdl1 axis regulates the proliferation and migration of amniotic fluid-derived mesenchymal stromal cells.Biochemical and Biophysical Research Communications, 2020, 527(1): 187-193.

[27]Wei, Xiaowei; Cao, Songying*; Ma, Wei; Zhang, Chaonan; Gu, Hui; Liu, Dan; Luo, Wenting; Bai, Yuzuo; Wang, Weilin; Yuan, Zhengwei*.Intra-Amniotic Delivery of CRMP4 siRNA Improves Mesenchymal Stem Cell Therapy in a Rat Spina Bifida Model.Molecular Therapy - Nucleic Acids, 2020, 20: 502-517.

[28]An Dong; Wei Xiaowei; Zhang Henan; Liu Dan; Ma Wei; Yuan Zhengwei*.Spatiotemporal expression of leukemia inhibitory factor receptor protein during neural tube development in embryos with neural tube defects.Neural Regen Res 2020 Apr;15(4) 705-711, 15(4): 705-711.

[29]Wang Lili; Fan Yang; Zhang Yi; Zhou Fenghua; Yuan Zhengwei*.SEMA3A rs7804122 polymorphism is associated with Hirschsprung disease in the Northeastern region of China.Birth Defects Research Part A-Clinical and Molecular Teratology.

[31]Zhang, Qiang; Yue, Yuanyi; Shi, Bei; Yuan, Zhengwei*.A Bibliometric Analysis of Cleft Lip and Palate-Related Publication Trends From 2000 to 2017.The Cleft Palate-Craniofacial Journal, 2019, 56(5): 658-669.

[32]Zhang, Henan; Guo, Yi; Gu, Hui; Wei, Xiaowei; Ma, Wei; Liu, Dan; Yu, Kun; Luo, Wenting; Ma, Ling; Liu, Yusi; Xue, Jia; Huang, Jieting; Wang, Yanfu; Jia, Shanshan; Dong, Naixuan; Wang, Hongyan*; Yuan, Zhengwei*.TRIM4 is associated with neural tube defects based on genome-wide DNA methylation analysis.Clinical Epigenetics, 2019, 11: 17.

[33]Zhang, He Nan; Guo, Yi; Ma, Wei; Xue, Jia; Wang, Wei Lin; Yuan, Zheng Wei*.MGMT is down-regulated independently of promoter DNA methylation in rats with all-trans retinoic acid-induced spina bifida aperta.Neural Regeneration Research, 2019, 14(2): 361-368.

[34]Gu, Hui; Chen, Lizhu; Xue, Jia; Huang, Tianchu; Wei, Xiaowei; Liu, Dan; Ma, Wei; Cao, Songying; Yuan, Zhengwei*.Expression profile of maternal circulating microRNAs as non-invasive biomarkers for prenatal diagnosis of congenital heart defects.Biomedicine & Pharmacotherapy, 2019, 109: 823-830. 

[35]Sun, Li; Yuan, Zhengwei; Jian, Lingyan; Jiang, Qinghua; Zhang, Siwen; Tan, Jichun*.The Modified Bushen Antai Recipe Upregulates Estrogen and Progesterone Receptors at the Maternal-Fetal Interface in Pregnant Rats with Mifepristone-Induced Pregnancy Loss.Evidence-Based Complementary and Alternative Medicine, 2019, 8312020.

[36]Liu Dan; Xue Jia; Liu Yusi; Gu Hui; Wei Xiaowei; Ma Wei; Luo Wenting; Ma Ling; Jia Shanshan; Dong Naixuan; Huang Jieting; Wang Yanfu; Yuan Zhengwei*. Inhibition of NRF2 signaling and increased reactive oxygen species during embryogenesis in a rat model of retinoic acid-induced neural tube defects.NeuroToxicology, 2018, 69: 84-92.

[37]Xu Xiao Yan; Wei Xiao Wei; Ma Wei; Gu Hui; Liu Dan; Yuan Zheng Wei*.Genome-Wide Screening of Aberrant Methylation Loci for Nonsyndromic Cleft Lip.Chinese Medical Journal, 2018, 131(17): 2055-+.

[38]Xue Jia; Gu Hui; Liu Dan; Ma Wei; Wei Xiaowei; Zhao Lianshuai; Liu Yusi; Zhang Chaonan; Yuan Zhengwei*.Mitochondrial dysfunction is implicated in retinoic acid-induced spina bifida aperta in rat fetuses.International Journal of Developmental Neuroscience, 2018, 68: 39-44.

[39]Gao Song; Wang Yicun; Wang Meng; Li Zhi; Zhao Zhiying; Wang Raymond X; Wu Rong; Yuan Zhengwei; Cui Ranji; Jiao Kai; Wang Lizhong; Ouyang Ling; Liu Runhua.MicroRNA-155, induced by FOXP3 through transcriptional repression of BRCA1, is associated with tumor initiation in human breast cancer.Oncotarget, 2017, 8(25): 41451-41464.

[40]Gao Song; Zhao Zhiying; Wu Rong; Zeng Yuecan; Zhang Zhenyong; Miao Jianing; Yuan Zhengwei*.Bone marrow mesenchymal stem cell transplantation improves radiation-induced heart injury through DNA damage repair in rat model.Radiation and Environmental Biophysics, 2017, 56(1): 63-77. 

[41]Li, Xiaoshuai; Yuan, Zhengwei*; Wei, Xiaowei; Li, Hui; Zhao, Guifeng; Miao, Jiaoning; Wu, Di; Liu, Bo; Cao, Songying; An, Dong; Ma, Wei; Zhang, Henan; Wang, Weilin; Wang, Qiushi; Gu, Hui.Application potential of bone marrow mesenchymal stem cell (BMSCs) based tissue-engineering for spinal cord defect repair in rat fetuses with spina bifida aperta.J Mater Sci Mater Med, 2016, 27(4): 77-77.

[42]Wang, Qiushi; Yang, Qiaoni; Wang, Zhe; Tong, Haixia; Ma, Liangyan; Zhang, Yi; Shan, Fengping; Meng, Yiming; Yuan, Zhengwei*.Comparative analysis of human mesenchymal stem cells from fetal-bone marrow, adipose tissue, and Warton's jelly as sources of cell immunomodulatory therapy.Hum Vaccin Immunother, 2016, 12(1): 85-96.

[43]Zhou, Feng-Hua; Fan, Yang; Wei, Xiao-Wei; Wang, Li-Li; Miao, Jia-Ning; Li, Hui; Shan, Li-Ping; Yuan, Zheng-Wei*.Enhanced expression of collapsin response mediator protein 4 in spinal cords of rat fetuses with spina bifida aperta.International Journal of Clinical and Experimental Medicine, 2016, 9(2): 1576-1584.

[44]Cao, Songying; Wei, Xiaowei; Li, Hui; Miao, Jianing; Zhao, Guifeng; Wu, Di; Liu, Bo; Zhang, Yi; Gu, Hui; Wang, Lili; Fan, Yang; An, Dong; Yuan, Zhengwei*.Comparative Study on the Differentiation of Mesenchymal Stem Cells Between Fetal and Postnatal Rat Spinal Cord Niche.Cell Transplantation, 2016, 25(6): 1115-1130.

[45]Chen, Lizhu; Gu, Hui; Li, Jun; Yang, Ze-Yu; Sun, Xiao; Zhang, Li; Shan, Liping; Wu, Lina; Wei, Xiaowei; Zhao, Yili; Ma, Wei; Zhang, Henan; Cao, Songying; Huang, Tianchu; Miao, Jianing; Yuan, Zhengwei.Comprehensive maternal serum proteomics identifies the cytoskeletal proteins as non-invasive biomarkers in prenatal diagnosis of congenital heart defects.Scientific Reports, 2016, 6: 19248-19248. 

[46]Cao, Songying; Wei, Xiaowei; Li, Hui; Miao, Jianing; Zhao, Guifeng; Wu, Di; Liu, Bo; Zhang, Yi; Gu, Hui; Wang, Lili; Fan, Yang; An, Dong; Yuan, Zhengwei.Comparative study on the differentiation of mesenchymal stem cells between fetal and postnatal rat spinal cord niche.Cell Transplantation, 2015.

[47]Ma, Wei; Wei, Xiaowei; Gu, Hui; Li, Hui; Guan, Kaoping; Liu, Dan; Chen, Lizhu; Cao, Songying; An, Dong; Zhang, Henan; Huang, Tianchu; Miao, Jianing; Zhao, Guifeng; Wu, Di; Liu, Bo; Wang, Weilin; Yuan, Zhengwei*.Sensory neuron differentiation potential of in utero mesenchymal stem cell transplantation in rat fetuses with spina bifida aperta.Birth Defects Res A Clin Mol Teratol, 2015, 103(9): 772-779.

[48]Ma, Wei; Wei, Xiaowei; Gu, Hui; Li, Hui; Guan, Kaoping; Liu, Dan; Chen, Lizhu; Cao, Songying; An, Dong; Zhang, Henan; Huang, Tianchu; Miao, Jianing; Zhao, Guifeng; Wu, Di; Liu, Bo; Wang, Weilin; Yuan, Zhengwei.Sensory neuron differentiation potential of in utero mesenchymal stem cell transplantation in rat fetuses with spina bifida aperta.Birth Defects Res A Clin Mol Teratol, 2015, 103(9): 772-779.

[49]An, Dong; Wei, Xiaowei; Li, Hui; Gu, Hui; Huang, Tianchu; Zhao, Guifeng; Liu, Bo; Wang, Weilin; Chen, Lizhu; Ma, Wei; Zhang, Henan; Cao, Songying; Yuan, Zhengwei.Identification of PCSK9 as a novel serum biomarker for the prenatal diagnosis of neural tube defects using iTRAQ quantitative proteomics.Scientific Reports, 2015, 5: 17559-17559.

[50]Tang, Xiao-Bing; Zhang, Jin; Wang, Wei-Lin; Yuan, Zheng-Wei; Bai, Yu-Zuo.Temporal and spatial expression of caudal-type homeobox proteins in the midgut of human embryos.International Journal of Clinical and Experimental Medicine, 2015, 8(11): 19895-19904.

[51]An, Dong; Wei, Xiaowei; Li, Hui; Gu, Hui; Huang, Tianchu; Zhao, Guifeng; Liu, Bo; Wang, Weilin; Chen, Lizhu; Ma, Wei; Zhang, Henan; Cao, Songying; Yuan, Zhengwei*.Identification of PCSK9 as a novel serum biomarker for the prenatal diagnosis of neural tube defects using iTRAQ quantitative proteomics.Sci Rep, 2015, 5: 17559-17559.

[52]Liu, Zhenjiang*; Yuan, Zhengwei; Zhao, Qun.SELDI-TOF-MS Proteomic Profiling of Serum, Urine, and Amniotic Fluid in Neural Tube Defects.PLos One, 2014, 9(7): e103276.

[53]Liu, Xiaomei*; Qi, Ying; Tian, Baoling; Chen, Dong; Gao, Hong; Xi, Chunyan; Xing, Yanlin; Yuan, Zhengwei.Maternal protein restriction induces alterations in hepatic tumor necrosis factor-alpha/CYP7A1 signaling and disorders regulation of cholesterol metabolism in the adult rat offspring.Journal of Clinical Biochemistry and Nutrition, 2014, 55(1): 40-47.

[54]Ng, R. C-L; Matsumaru, D.; Ho, A. S-H; Garcia-Barcelo, M-M; Yuan, Z-W; Smith, D.; Kodjabachian, L.; Tam, P. K-H; Yamada, G.; Lui, V. C-H*.Dysregulation of Wnt inhibitory factor 1 (Wif1) expression resulted in aberrant Wnt-beta-catenin signaling and cell death of the cloaca endoderm, and anorectal malformations.Cell Death and Differentiation, 2014, 21(6): 978-989.

[55]Zhang, Shu-Cheng; Chen, Fang; Jiang, Kai-Lei; Yuan, Zheng-Wei; Wang, Wei-Lin*.Comparative proteomic profiles of the normal and aganglionic hindgut in human Hirschsprung disease.Pediatric Research, 2014, 75(6): 754-761.

[56]Zhang, Shucheng; Jiang, Kailei; Yuan, Zhengwei; Wang, Weilin*.The single nucleotide polymorphisms in Smad-interacting protein 1 gene contribute to its ectopic expression and susceptibility in Hirschsprung's disease.Experimental and Molecular Pathology, 2014, 96(2): 219-224.

[57]Li, Hui; Miao, Jianing; Zhao, Guifeng; Wu, Di; Liu, Bo; Wei, Xiaowei; Cao, Songying; Gu, Hui; Zhang, Yi; Wang, Lili; Fan, Yang; Yuan, Zhengwei*.Different expression patterns of growth factors in rat fetuses with spina bifida aperta after in utero mesenchymal stromal cell transplantation.Cytotherapy, 2014, 16(3): 319-330.

[58]Li H, Miao J, Zhao G, Wu D, Liu B, Cao S, Zhou F, Gu H, Wang L, Fan Y, Yuan Z*.Different expression pattern of growth factors in rat fetuses with spina bifida aperta after in utero mesenchymal stem cell transplantation. Cytotherapy. 2014, 16(3): 319-330.

[59]Zhang, Shu-Cheng; Wang, Wei-Lin*; Su, Peng-Jun; Jiang, Kai-Lei; Yuan, Zheng-Wei。Decreased enteric fatty acid amide hydrolase activity is associated with colonic inertia in slow transit constipation.Journal of Gastroenterology and Hepatology, 2014, 29(2): 276-283.

[60]Wang, Li-Li; Gu, Hui; Fan, Yang; Zhang, Yi; Wu, Di; Miao, Jia-Ning; Huang, Tian-Chu; Li, Hui; Yuan, Zheng-Wei*.Up-regulated FHL1 Expression Maybe Involved in the Prognosis of Hirschsprung's Disease.International Journal of Medical Sciences, 2014, 11(3): 262-267.

[61]Wei X, Li H, Miao J, Liu B, Zhan Y, Wu D, Zhang Y, Wang L, Fan Y, Gu H, Wang W, Yuan Z. miR-9*- and miR-124a-Mediated Switching of Chromatin Remodelling Complexes is Altered in Rat Spina Bifida Aperta.Neurochemical Research, 2013, 38(8): 1605-1615.

[62]Wu, Li-na; Wei, Xiao-wei; Fan, Yang; Miao, Jia-ning; Wang, Li-li; Zhang, Yi; Wu, Di; Yuan, Zheng-wei*.Altered Expression of 14-3-3 zeta Protein in Spinal Cords of Rat Fetuses with Spina Bifida Aperta.PLos One, 2013, 8(8): e70457.

[63]Wu L, Wei X, Fan Y, Miao J, Wang L, Zhang Y, Wu D, Yuan Z. Altered Expression of 14-3-3 ζ Protein in Spinal Cords of Rat Fetuses with Spina Bifida Aperta. Plos One. 2013, 8(8).

[64]Wei, Xiaowei; Li, Hui*; Miao, Jianing; Liu, Bo; Zhan, Yue; Wu, Di; Zhang, Yi; Wang, Lili; Fan, Yang; Gu, Hui; Wang, Weilin; Yuan, Zhengwei.miR-9*- and miR-124a-Mediated Switching of Chromatin Remodelling Complexes is Altered in Rat Spina Bifida Aperta.Neurochemical Research, 2013, 38(8): 1605-1615. 

[65]Fan, Yang; Wang, Lili; Zhang, Yi; Huang, Tianchu; Li, Hui; Gu, Hui; Wang, Weilin; Yuan, Zhengwei*.Comparative proteomics of Hirschsprung's disease.Journal of Proteomics, 2013, 84: 176-184.

[66]Liu, Xiaomei*; Qi, Ying; Gao, Hong; Jiao, Yisheng; Gu, Hui; Miao, Jianing; Yuan, Zhengwei。Maternal protein restriction induces alterations in insulin signaling and ATP sensitive potassium channel protein in hypothalami of intrauterine growth restriction fetal rats.Journal of Clinical Biochemistry and Nutrition, 2013, 52(1): 43-48. 

[67]Zhang, Tao; Tang, Xiao Bing; Wang, Li Li; Bai, Yu Zuo*; Qiu, Guang Rong; Yuan, Zheng Wei; Wang, Wei Lin.Mutations and Down-Regulation of CDX1 in Children with Anorectal Malformations.International Journal of Medical Sciences, 2013, 10(2): 191-197.

[68]Yin, Shui Jing; Tang, Xiao Bing; Li, Fei Fei; Zhang, Tao; Yuan, Zheng Wei; Wang, Wei Lin; Bai, Yu Zuo*.Spatiotemporal Expression of Fibroblast Growth Factor 10 in Human Hindgut and Anorectal Development.Cells Tissues Organs, 2013, 198(1): 28-34. 

[69]Ma, Yinghuan; Bao, Yongxin; Li, Chenghao; Jiao, Fubin; Xin, Hongjie; Yuan, Zhengwei*.Correlation between spina bifida manifesta in fetal rats and c-Jun N-terminal kinase signaling.Neural Regeneration Research, 2012, 7(32): 2485-2491.

[70]Zhang, Shu-Cheng*; Wang, Wei-Lin; Cai, Wei-Song; Jiang, Kai-Lei; Yuan, Zheng-Wei.Engineered measles virus Edmonston strain used as a novel oncolytic viral system against human hepatoblastoma.BMC Cancer, 2012, 12: 427. 

[71]Liu, Xiaomei; Wang, Aiyuan; Gao, Hong; Yuan, Zhengwei; Jiao, Yisheng*.Expression and role of the inhibitor of apoptosis protein livin in chemotherapy sensitivity of ovarian carcinoma.International Journal of Oncology, 2012, 41(3): 1021-1028.

[72]Gu, Hui; Li, Hui; Zhang, Li; Luan, Hong; Huang, Tianchu; Wang, Lili; Fan, Yang; Zhang, Yi; Liu, Xiaomei; Wang, Weilin; Yuan, Zhengwei*.Diagnostic role of microRNA expression profile in the serum of pregnant women with fetuses with neural tube defects.Journal of Neurochemistry, 2012, 122(3): 641-649. 

[73]Wei, Xiaowei; Li, Hui; Miao, Jianing; Zhou, Fenghua; Liu, Bo; Wu, Di; Li, Shujing; Wang, Lili; Fan, Yang; Wang, Weilin; Yuan, Zhengwei*.Disturbed apoptosis and cell proliferation in developing neuroepithelium of lumbo-sacral neural tubes in retinoic acid-induced spina bifida aperta in rat.International Journal of Developmental Neuroscience, 2012, 30(5): 375-381. 

[74]Li, Hui; Gao, Fei; Ma, Lili; Jiang, Junhong; Miao, Jianing; Jiang, Mingyu; Fan, Yang; Wang, Lili; Wu, Di; Liu, Bo; Wang, Weilin; Lui, Vincent Chi Hang; Yuan, Zhengwei*.Therapeutic potential of in utero mesenchymal stem cell (MSCs) transplantation in rat foetuses with spina bifida aperta.Journal of Cellular and Molecular Medicine, 2012, 16(7): 1606-1617. 

[75]Shan Liping; Fan Yang; Li Hui; Yuan Zhengwei*.Proteomic analysis of amniotic fluid of pregnant rats with spina bifida aperta.Journal of Proteomics, 2012, 75(4): 1181-1189. 

[76]Fan, Yang; Wang, Lili; Zhou, Fenghua; Zhang, Yi; Li, Hui; Shan, Liping; Yuan, Zhengwei*.Comparative proteomics of spinal cords of rat fetuses with spina bifida aperta.Journal of Proteomics, 2011, 75(2): 668-676.

[77]So, Man-Ting*; Leon, Thomas Yuk-Yu; Cheng, Guo; Tang, Clara Sze-Man; Miao, Xiao-Ping; Cornes, Belinda K.; Diem Ngoc Ngo; Cui, Long; Ngan, Elly Sau-Wai; Lui, Vincent Chai-Hang; Wu, Xuan-Zhao; Wang, Bin; Wang, Hualong; Yuan, Zheng-Wei; Huang, Liu-Ming; Li, Long; Xia, Huimin; Zhu, Deli; Liu, Juncheng; Thanh Liem Nguyen; Chan, Ivy Hau-Yee; Chung, Patrick Ho-Yu; Liu, Xue-Lai; Zhang, Ruizhong; Wong, Kenneth Kak-Yuen; Sham, Pak-Chung; Cherny, Stacey S.; Tam, Paul Kwong-Hang.RET Mutational Spectrum in Hirschsprung Disease: Evaluation of 601 Chinese Patients.PLos One, 2011, 6(12): e28986.

[78]Ju, Jun-Jie; Gao, Hong; Li, Hui; Lu, Yao; Wang, Li-Li; Yuan, Zheng-Wei*.No association between the SNPs (rs56134796; rs3824934; rs41302375) in the TRPC6 gene promoter and infantile hypertrophic pyloric stenosis in Chinese people.Pediatric Surgery International, 2011, 27(12): 1267-1270.

[79]Deb, Dilip K.; Wang, Youli; Zhang, Zhongyi; Nie, Hongguang; Huang, Xueshi; Yuan, Zhengwei; Chen, Yunzi; Zhao, Qun*; Li, Yan Chun.Molecular Mechanism Underlying 1,25-Dihydroxyvitamin D Regulation of Nephrin Gene Expression.Journal of Biological Chemistry, 2011, 286(37): 32011-32017.

[80]Wang, Li-Li; Fan, Yang; Zhou, Feng-hua; Li, Hui; Zhang, Yi; Miao, Jia-Ning; Gu, Hui; Huang, Tian-Chu; Yuan, Zheng-Wei*.Semaphorin 3A Expression in the Colon of Hirschsprung Disease.Birth Defects Research Part A-Clinical and Molecular Teratology, 2011, 91(9): 842-847.

[81]Chen, Qing Jiang; Jia, Hui Min; Niu, Zhi Xin; Zhang, Tao; Bai, Yu Zuo; Yuan, Zheng Wei; Wang, Wei Lin*.The Development of Satellite Cells and Their Niche in Striated Muscle Complex of Anorectal Malformations Rat Embryos.Journal of Surgical Research, 2011, 168(1).

[82]Yue, Xiaohong; Fu, Jianhua; Xue, Xindong; Gao, Hong; Liu, Dongyan; Zong, Zhihong; Wang, Wei; Li, Hui; Yuan, Zhengwei.Detection of p16 promoter methylation in premature rats with chronic lung disease induced by hyperoxia.Pediatrics International, 2010, 52(4): 520-526.

[83]Miao, Xiaoping; Leon, Thomas Yuk-Yu; Ngan, Elly Sau-Wai; So, Man-Ting; Yuan, Zheng-Wei; Lui, Vincent Chi-Hang; Chen, Yan; Wong, Kenneth Kak-Yuen; Tam, Paul Kwong-Hang; Garcia-Barcelo, Merce.Reduced RET expression in gut tissue of individuals carrying risk alleles of Hirschsprung's disease.Human Molecular Genetics, 2010, 19(8): 1461-1467.

[84]Wang, Li-Li; Qiu, Guang-Rong; Fu, Wei-Neng; Yuan, Zheng-Wei; Sun, Kai-Lai.Transcriptional regulation of Fhl1 by estradiol in rat myoblastocytes.Steroids, 2010, 75(4-5): 368-372.

[85]Li, Yong; Hou, Xiang-Yu; Yuan, Zheng-Wei; Wang, Wei-Lin*.Quantitative analysis of motor neurons of the levator ani muscle in fetal rats with spina bifida occulta.Surgical Neurology, 2009, 72(6): 652-656.

[86]Chen, Qing Jiang; Jia, Hui Min; Zhang, Shi Wei; Zhang, Shu Cheng; Bai, Yu Zuo; Yuan, Zheng Wei; Wang, Wei Lin.Apoptosis during the development of pelvic floor muscle in anorectal malformation rats.Journal of Pediatric Surgery, 2009, 44(10): 1884-1891.

[87]Guan, Kaoping; Li, Hui; Fan, Yang; Wang, Weilin; Yuan, Zhengwei*.Defective Development of Sensory Neurons Innervating the Levator Ani Muscle in Fetal Rats with Anorectal Malformation.Birth Defects Research Part A: Clinical and Molecular Teratology , 2009, 85(7): 583-587.

[88]Wang, Da-Jia; Bai, Yu-Zuo; Zhang, Shi-Wei; Gao, Hong; Zhang, Shu-Cheng; Zhang, Dan; Zhang, Tao; Yuan, Zheng-Wei; Wang, Wei-Lin.Expression of EphB2 in the development of anorectal malformations in fetal rats.Journal of Pediatric Surgery, 2009, 44(3): 592-599.

[89]Yuan, Zhengwei*; Cheng, Wei; Hou, Ana; Wang, Wei; Zhang, Shucheng; Liu, Dan; Ga, Fei; Li, Hui; Wang, Weilin.Constipation Is Associated With Spina Bifida Occulta in Children.Clinical Gastroenterology and Hepatology, 2008, 6(12): 1348-1353.

[90]Xie, Yi; Chan, Hiuman; Fan, Jianqing; Chen, Yongxiong; Young, Joseph; Li, Wen; Miao, Xiaoping; Yuan, Zhengwei; Wang, Huanmin; Tam, Paul K. H.; Ren, Yi.Involvement of visinin-like protein-1 (VSNL-1) in regulating proliferative and invasive properties of neuroblastoma.Carcinogenesis, 2007, 28(10): 2122-2130.

[91]Huimin Jia; Keren Zhang; Shucheng Zhang; Zhengwei Yuan; Yuzuo Bai; Weilin Wang.Quantitative analysis of sacral parasympathetic nucleus innervating the rectum in rats with anorectal malformation.Journal of Pediatric Surgery, 2007, 42(9): 1544-1548.

[92]Cai, WeiSong; Zhao, HongYu; Guo, JunBin; Li, Yong; Yuan, ZhengWei; Wang, WeiLin.Retinoic acid-induced lumbosacral neural tube defects: myeloschisis and hamartoma.Child's Nervous System, 2007, 23(5): 549-554.

[93]Ngan, Elly S. W.; Sit, Francesco Y. L.; Lee, King Liu; Mia, Xiaoping; Yuan, Zhengwei; Wang, Weilin; Nicholls, John M.; Wong, Kenneth K. Y.; Garcia-Barcelo, Merce; Lui, Vincent C. H.; Tam, Paul K. H..Implications of endocrine gland-derived vascular endothelial growth factor/prokineticin-1 signaling in human neuroblastoma progression.Clinical Cancer Research, 2007, 13(3): 868-875.

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[11]伍麗婷, 薛佳, 李詩萌, 袁正偉*. 孕婦不同孕周血清堿性磷酸酶變化規(guī)律的隊列研究[J]. 發(fā)育醫(yī)學電子雜志, 2021, 9 (01): 43-48.

[12]黃天楚, 顧卉*, 袁正偉. 胎兒先天性心臟病無創(chuàng)性產(chǎn)前篩查分子標志物的研究進展[J]. 發(fā)育醫(yī)學電子雜志, 2020, 8 (03): 267-271.

[13]袁正偉*. 神經(jīng)管畸形發(fā)病機制研究進展與新策略[J]. 發(fā)育醫(yī)學電子雜志, 2020, 8 (03): 205-207+183.

[14]楊中華, 王大斌, 劉丹, 賈慧敏, 白玉作, 王維林, 袁正偉*. 先天性肛門直腸畸形術后合并便秘患兒排便功能評定及病因探討[J]. 臨床小兒外科雜志, 2020, 19 (01): 18-25.

[15]董乃萱, 顧卉, 劉丹, 魏曉偉, 馬巍, 馬玲, 袁正偉*. 孕婦血清淀粉樣P物質(zhì)作為神經(jīng)管缺陷產(chǎn)前標志物的研究[J]. 中國醫(yī)科大學學報, 2019, 48 (10): 883-886.

[16]安東*, 袁正偉. 差異蛋白質(zhì)組學在神經(jīng)系統(tǒng)疾病生物標志物篩選中的研究進展[J]. 山東醫(yī)藥, 2019, 59 (22): 89-92.

[17]安東*, 袁正偉. 利用同位素標記相對和絕對定量技術篩查神經(jīng)管畸形胚胎孕鼠血清差異蛋白質(zhì)譜[J]. 中國醫(yī)科大學學報, 2019, 48 (04): 315-319+323.

[18]顧卉, 陳驪珠, 薛佳, 黃天楚, 袁正偉*. 先天性心臟病胎兒母體血清中的microRNA表達譜及其診斷意義[J]. 發(fā)育醫(yī)學電子雜志, 2019, 7 (01): 32-37.

張超楠; 馬巍; 曹嵩穎; 魏曉偉; 顧卉; 羅文婷; 薛佳; 趙連帥; 黃天楚; 袁正偉*.羊膜腔注射Ad-eGFP對顯性脊柱裂胎鼠脊髓缺損區(qū)域轉染效果的研究.中華小兒外科雜志, 2019, 40(2): 172-176.

薛佳; 劉丹; 顧卉; 魏曉偉; 馬巍; 趙連帥; 張超楠; 黃天楚; 袁正偉*.血清銅和血清銅藍蛋白活力測定對神經(jīng)管畸形孕鼠診斷價值的研究.中華小兒外科雜志, 2019, 40(1): 53-57.

[19]張強, 袁正偉. 蛋白質(zhì)組學技術在妊娠期母胎疾病診斷中的應用研究進展[J]. 中國實用婦科與產(chǎn)科雜志, 2018, 34 (06): 700-704.

[20]袁正偉. 先天畸形的胚胎早期診斷與治療新進展[J]. 發(fā)育醫(yī)學電子雜志, 2018, 6 (02): 69-73.

[21]陳驪珠, 張墨, 馬巍, 袁正偉. 蛋白質(zhì)組學技術在產(chǎn)前診斷生物標志物篩查中的研究進展[J]. 中華全科醫(yī)學, 2018, 16 (03): 461-464.

[22]陳驪珠, 張墨, 馬巍, 袁正偉. 質(zhì)譜多反應監(jiān)測技術篩查先天性心臟畸形蛋白標志物的價值[J]. 中華實用診斷與治療雜志, 2018, 32 (01): 14-17.

[23]陳驪珠, 馬巍, 張墨, 袁正偉. 應用iTRAQ技術篩選先天性心臟畸形胎兒母親血清差異表達蛋白[J]. 中國醫(yī)科大學學報, 2017, 46 (06): 510-514+518.

[24]馬麗麗, 徐延波, 袁正偉. 經(jīng)臍單孔腹腔鏡治療小兒復雜性闌尾炎的療效分析[J]. 中國內(nèi)鏡雜志, 2017, 23 (05): 13-18.

[25]王秋實, 劉學勇, 王哲, 楊巧妮, 佟海俠, 馬良艷, 張一, 苗佳寧, 袁正偉. 干擾素-γ對脂肪間充質(zhì)干細胞免疫調(diào)節(jié)相關基因表達的影響[J]. 解剖科學進展, 2016, 22 (04): 375-378+381.

[26]趙桂鋒, 劉波, 苗佳寧, 吳迪, 李慧, 黃天楚, 袁正偉. 先天性顯性脊椎裂胎鼠宮內(nèi)干細胞移植新方法的建立[J]. 山東醫(yī)藥, 2016, 56 (16): 8-10+110.

[27]袁正偉. 先天性肛門直腸畸形病因?qū)W研究新進展[J]. 發(fā)育醫(yī)學電子雜志, 2016, 4 (01): 8-12.

[28]魏曉偉, 袁正偉. 反式維甲酸誘導顯性脊柱裂胎鼠骶尾部神經(jīng)前體細胞凋亡和增殖的變化規(guī)律研究[J]. 發(fā)育醫(yī)學電子雜志, 2015, 3 (01): 42-46.

[29]劉振江, 袁正偉, 趙群. SELDI技術對開放性脊柱裂胎鼠羊水蛋白質(zhì)組學的初步分析[J]. 中國醫(yī)科大學學報, 2014, 43 (01): 26-30+33.

[30]劉曉梅, 焦伊勝, 顧卉, 苗佳寧, 袁正偉. 宮內(nèi)生長受限子鼠肝臟脂肪代謝關鍵酶表達的研究[J]. 中國現(xiàn)代醫(yī)學雜志, 2013, 23 (20): 7-11.

[31]范洋, 苗佳寧, 袁正偉. 雙向電泳—飛行時間串聯(lián)質(zhì)譜對先天性脊柱裂大鼠脊髓差異表達蛋白的鑒定[J]. 中國醫(yī)科大學學報, 2012, 41 (06): 561-563.

[32]馬英桓, 袁正偉. 維甲酸誘導脊柱裂胎鼠脊髓組織中Caspase-3表達情況[J]. 中國臨床解剖學雜志, 2012, 30 (03): 311-314.

[33]劉曉梅, 顧卉, 邢艷琳, 袁正偉. 宮內(nèi)生長受限胎兒和早期新生兒循環(huán)中炎癥標志物變化研究[J]. 中國實用兒科雜志, 2011, 26 (12): 937-939.

[34]顧卉, 佟宇鑫, 劉彤, 李慧, 李丹妮, 袁正偉. GST-LMO1融合蛋白表達載體的構建及其在原核細胞中的表達[J]. 中國醫(yī)科大學學報, 2011, 40 (11): 961-963+978.

[35]顧卉, 佟宇鑫, 劉彤, 李妍, 李丹妮, 袁正偉. hLMO3基因真核表達載體的構建及蛋白的表達和定位[J]. 解剖科學進展, 2011, 17 (04): 347-350.

[36]劉振江, 袁正偉, 趙群. 表面增強激光解析/離子化飛行時間質(zhì)譜技術在神經(jīng)管缺陷胎兒母親血清、尿液和羊水蛋白質(zhì)標志物篩查中的研究[J]. 中國現(xiàn)代醫(yī)學雜志, 2010, 20 (05): 738-746.

[37]劉振江, 袁正偉, 趙群, 宋丹丹. 表面增強激光解析/離子化飛行時間質(zhì)譜技術在神經(jīng)管缺陷胎兒母親血清標志物篩查中的應用[J]. 中國婦幼保健, 2010, 25 (05): 650-654.

[38]侯阿娜, 袁正偉, 王維林. 隱性脊柱裂脊髓內(nèi)NOS1、脂肪及尼氏體含量的組織學分析[J]. 山東醫(yī)藥, 2010, 50 (04): 6-8.

[39]王莉莉, 婁毅, 方長清, 袁正偉. 東北地區(qū)漢族人群XPD單核苷酸多態(tài)性與結腸癌易感相關性的研究[J]. 中華腫瘤防治雜志, 2009, 16 (17): 1284-1286.

[40]高飛, 李文豪, 蔣俊紅, 袁正偉. 小兒異位胃黏膜癥57例分析[J]. 中國誤診學雜志, 2009, 9 (13): 3198-3199.

[41]劉振江, 袁正偉, 趙群. 表面增強激光解析離子化飛行時間質(zhì)譜技術研究神經(jīng)管缺陷胎兒母親尿液中蛋白質(zhì)譜改變規(guī)律[J]. 中國醫(yī)科大學學報, 2009, 38 (03): 220-224.

[42]李慧, 袁正偉. 腦脊液中微量的可溶型晚期糖基化終末產(chǎn)物受體檢測方法建立與初步應用[J]. 中國醫(yī)科大學學報, 2009, 38 (03): 175-177.

[43]李慧, 袁正偉, 陳巖, 譚廣亨. CD28/B7和CD134/CD134L共刺激通路阻斷與免疫抑制劑聯(lián)合治療對移植心臟存活時間影響[J]. 解剖科學進展, 2009, 15 (01): 60-64.

[44]賈慧敏, 陳青江, 張濤, 白玉作, 袁正偉, 王維林. Cajal間質(zhì)細胞及突觸素在肛門直腸畸形動物模型末端直腸壁的表達及意義[J]. 中國醫(yī)科大學學報, 2009, 38 (01): 11-14.

[45]袁正偉, 白玉作, 王偉. 第6屆全國小兒肛腸、肝膽、新生兒外科學術研討會紀要[J]. 臨床小兒外科雜志, 2008, 7 (06): 79.

[46]胡淑敏, 袁正偉, 馬怡然, 方文剛, 朱麗, 陳譽華. nNOS和iNOS在神經(jīng)管畸形胎鼠大腦皮質(zhì)中的表達及意義[J]. 解剖科學進展, 2007, (02): 107-110.

[47]楊屹, 李勇, 王常林, 袁正偉. 隱性脊柱裂動物模型脊髓神經(jīng)遞質(zhì)表達的研究[J]. 中華小兒外科雜志, 2007, 28 (04): 204-207.

[48]管考平, 袁正偉, 王維林, 高飛, 蘇鵬俊. 先天性肛門直腸畸形胎鼠支配肛提肌感覺神經(jīng)元定量研究[J]. 中華醫(yī)學雜志, 2007, 87 (02): 131-133.

[49]張海蘭, 高紅, 袁正偉, 王維林. 肛門直腸畸形直腸末端c-kit和干細胞因子受體表達的研究[J]. 中華小兒外科雜志, 2006, (12): 631-634.

[50]李劍明, 袁正偉, 徐微娜, 于樹鵬, 張彩霞, 裴著果. 核素顯像在無肛畸形術后患兒排便功能中的初步研究[J]. 中國醫(yī)學影像技術, 2006, (09): 1409-1411.

[51]劉丹, 牛之彬, 袁正偉. 128例小兒術后中心靜脈壓導管的應用與護理[J]. 小兒急救醫(yī)學, 2005, (06): 502-503.

[52]李勇, 王維林, 袁正偉, 白玉作, 楊屹, 蔡煒嵩. 隱性脊椎裂胎鼠支配肛提肌脊髓運動神經(jīng)元定量研究[J]. 中華小兒外科雜志, 2005, (12): 658-661.

[53]劉丹,牛之彬,袁正偉. 對肛門成形術后便失禁患者實施生物反饋訓練的護理[J]. 中華護理雜志, 2005, (11): 26-27.

[54]楊屹,李勇,王常林,袁正偉. 顯性脊柱裂動物模型膀胱膽堿乙酰轉移酶多巴胺β羥化酶和降鈣素基因相關肽表達的研究[J]. 中國當代兒科雜志, 2005, (04): 354-356.

[55]劉丹,牛之彬,袁正偉. 兒童股骨頭骨骺滑脫治療中的護理[J]. 解放軍護理雜志, 2005, (07): 58-59.

[56]蔡煒嵩,趙紅宇,袁正偉. 膠質(zhì)細胞源性神經(jīng)營養(yǎng)因子對運動神經(jīng)元發(fā)育及運動神經(jīng)元性疾病的作用[J]. 中國修復重建外科雜志, 2005, (06): 490-493.

[57]王偉,史立偉,袁正偉,王維林. 應用生物反饋訓練無肛術后患兒的排便功能(英文)[J]. 中國臨床康復, 2005, (23): 214-215.

[58]高飛,袁正偉. 骨髓間充質(zhì)干細胞的體外培養(yǎng)、誘導分化及在神經(jīng)系統(tǒng)疾病中的應用[J]. 國外醫(yī)學(兒科學分冊), 2005, (03): 191-193.

[59]王偉,袁正偉,王維林. 三維向量測壓在無肛術后患兒排便功能隨訪與康復治療中的應用[J]. 中國醫(yī)科大學學報, 2005, (01): 74-76.

[60]侯翔宇,王維林,袁正偉,張樹成,白玉作. 脊髓拴系綜合征術后結腸傳輸時間測定及意義[J]. 中華小兒外科雜志, 2005, (02): 12-14.

[61]張樹成,王維林,白玉作,袁正偉. 結腸傳輸時間測定和直腸肛管測壓在兒童便秘中的意義[J]. 中國當代兒科雜志, 2005, (01): 39-42.

[62]蔡煒嵩,袁正偉,郭俊斌,李勇,王維林. 維甲酸致大鼠胚胎神經(jīng)管畸形的組織形態(tài)學觀察[J]. 中華小兒外科雜志, 2004, (05): 50-53.

[63]李勇,王維林,袁正偉,白玉作,蔡煒嵩. 脊柱裂動物模型制作與胚胎發(fā)生機制探討[J]. 中華小兒外科雜志, 2004, (05): 54-59.

[64]王偉,袁正偉. 生物反饋訓練治療無肛患兒術后大便失禁[J]. 中華物理醫(yī)學與康復雜志, 2004, (06): 25-26.

[65]賈慧敏,王維林,袁正偉,白玉作. 先天性肛門直腸畸形胎鼠腰骶髓副交感神經(jīng)元發(fā)育異常的研究[J]. 中華小兒外科雜志, 2004, (03): 87-89.

[66]蘇琪,吳碩東,袁正偉,王偉,殷紅專,韓霞,劉恩卿. 直腸癌術后肛門外括約肌神經(jīng)電生理研究[J]. 中國臨床康復, 2004, (17): 3308-3309.

[67]袁正偉,王維林,李劍明. 核素排便造影在小兒便秘診斷中的應用價值[J]. 中華兒科雜志, 2004, (05): 42-45+85.

[68]李勇,王維林,袁正偉,楊屹,賈慧敏,蔡煒嵩. 一種簡捷可靠的胎鼠骨和軟骨雙重染色技術[J]. 中國醫(yī)科大學學報, 2004, (02): 96-97.

[69]袁正偉,王維林,白玉作,王偉. 針對性生物反饋訓練的長期療效隨訪[J]. 中華醫(yī)學雜志, 2004, (06): 42-45.

[70]李勇,王維林,袁正偉,白玉作,楊屹,蔡煒嵩. 丙戊酸誘導胎鼠發(fā)生隱性脊椎裂畸形的模型建立[J]. 中國當代兒科雜志, 2004, (01): 38-41+1.

[71]曲日斌,張樹成,王維林,白玉作,袁正偉. 小兒便秘結腸動力學機制的初步探討[J]. 中華普通外科雜志, 2003, (08): 21-23.

[72]袁正偉,王維林,譚廣亨. 先天性肛門直腸畸形支配盆底肌的脊髓神經(jīng)元定量研究[J]. 中華醫(yī)學雜志, 2003, (14): 70-73.

[73]張樹成,王維林,白玉作,袁正偉. 先天性巨結腸術后結腸傳輸時間測定的意義[J]. 中華小兒外科雜志, 2003, (02): 23-25.

[74]白玉作,王維林,王偉,袁正偉. 大鼠肛門直腸畸形的胚胎發(fā)育研究[J]. 中華小兒外科雜志, 2003, (02): 58-61+98.

[75]張樹成,王維林,白玉作,袁正偉,王偉. 便秘患兒的胃腸傳輸時間測定及其意義[J]. 中華兒科雜志, 2003, (03): 20-23+84.

[76]袁正偉,王維林,李劍明,白玉作,李正,吉士俊. 先天性無肛畸形排便功能的研究[J]. 中華小兒外科雜志, 2002, (03): 35-37.

[77]白玉作,陳輝,王維林,王偉,袁正偉,李正. 肛門直腸畸形患兒術后30年以上生活質(zhì)量觀察[J]. 中華小兒外科雜志, 2001, (01): 24-26.

[78]袁正偉,王維林,吉士俊,李正,王慧貞. 先天性無肛畸形患兒肛門外括約肌神經(jīng)電生理研究[J]. 中華醫(yī)學雜志, 2000, (01): 33-36.

[79]袁正偉,陳蘇彥,王維林,王五洲. 易蒙停治療小兒便失禁的臨床應用[J]. 遼寧藥物與臨床, 1999, (04): 15.

[80]袁正偉,吉士俊,王維林,王慧貞,李正. 先天性肛門閉鎖術后大便失禁的生物反饋治療[J]. 中華小兒外科雜志, 1999, (05): 7-11.

[81]袁正偉,王慧貞,王維林,李正,吉士俊. 排便造影方法對先天性無肛畸形術后肛門直腸功能的評價[J]. 中華小兒外科雜志, 1999, (01): 21-23.

[82]袁正偉，李正，王練英，王偉. 先天性食管裂孔疝患兒手術前后胃食管測壓研究[J]. 中國醫(yī)科大學學報, 1996, (02): 151-154.

[83]袁正偉，李正，王練英，王偉. 先天性上消化道梗阻患兒手術前后胃食管測壓研究[J]. 中國醫(yī)科大學學報, 1996, (01): 70-73.

[84]袁正偉，李正，王練英，王偉. 先天性上消化道梗阻患兒術前、后胃食管測壓研究[J]. 中華小兒外科雜志, 1995, (02): 104.

[85]袁正偉，李正，王練英，王偉. 正常新生兒、嬰幼兒胃及食管壓力測定[J]. 中國醫(yī)科大學學報, 1994, (04): 374-377.

       會議論文： 

[1]趙桂鋒, 劉波, 苗佳寧, 吳迪, 李慧 &  袁正偉. (2012). 宮內(nèi)干細胞移植治療先天性脊椎裂胎鼠的新方法探討. (eds.) 第十屆中國實驗動物科學年會論文集 (pp.353-355).

[2]魏曉偉, 李慧 &  袁正偉. (2010). 利用全胚胎體培養(yǎng)方法研究維甲酸對大鼠胚胎的致畸機制. (eds.) 中華醫(yī)學會第八次全國小兒外科學術會論文集 (pp.140-141).

[3]吳迪, 李慧 &  袁正偉. (2010). 單細胞克隆的挑選與培養(yǎng). (eds.) 中華醫(yī)學會第八次全國小兒外科學術會論文集 (pp.424).

[4]顧卉 & 袁正偉. (2010). PAX3 mRNA在胎兒患有先天脊柱裂孕婦外周血中表達顯著降低. (eds.) 中華醫(yī)學會第八次全國小兒外科學術會論文集 (pp.118).

[5]李慧, 吳迪, 苗佳寧 &  袁正偉. (2010). 胚胎期骨髓間充質(zhì)干細胞移植治療顯性脊柱裂的研究. (eds.) 中華醫(yī)學會第八次全國小兒外科學術會論文集 (pp.93).

[6]賈慧敏, 陳青江, 張濤, 白玉作, 袁正偉 &  王維林. (2010). Notch-1及其受體Jagged-2在肛門直腸畸形大鼠末端直腸腸神經(jīng)系統(tǒng)發(fā)育過程中的表達變化. (eds.) 中華醫(yī)學會第八次全國小兒外科學術會論文集 (pp.248).

[7]張濤, 白玉作, 張海蘭, 賈慧敏, 袁正偉 &  王維林. (2010). Cdx1基因與先天性肛門直腸畸形的相關研究. (eds.) 中華醫(yī)學會第八次全國小兒外科學術會論文集 (pp.248-249).

[8]蘇琪, 吳碩東, 袁正偉, 王偉, 殷紅專, 韓霞 &  劉恩卿. (2004). 直腸癌保肛手術后肛門功能障礙的生物反饋治療. (eds.) 第九屆中日大腸肛門病學術交流會暨2004’中國肛腸外科論壇論文匯編 (pp.108-112).

[9]Cao, S. Y.; Yuan, Z. W.。Therapeutic Potential of RNAi Silencing CRMP-4 Combined with MSCs in Animal Models with Spina Bifida Aperta

[10]Ng, Roy Chun Laam; Lui, Vincent Chi Hang; Garcia-Barcelo, Maria-Mercedes; Yuan, Zheng Wei; Tam, Paul Kwong Hang。Wnt antagonists regulate urethra tubercularization and cloaca septation。16th Annual Conference of the International-Society-of-Development-Biologists, 2009-09-06 to 2009-09-10.

[11]Tam, P. K. H.; Tang, C. S. M.; Ngan, E. S. W.; Lui, V. C. H.; Chen, Y.; So, M. T.; Leon, T. Y. Y.; Miao, X. P.; Shum, C. K. Y.; Liu, F. Q.; Yeung, M. Y.; Yuan, Z. W.; Guo, W. H.; Liu, L.; Sun, X. B.; Huang, L. M.; Tou, J. F.; Song, Y. Q.; Chan, D.; Cheung, K. M. C.; Wong, K. K. Y.; Cherny, S. S.; Sham, P. C.; Garcia-Barcelo, M. M.Genome-wide association study identifies NRG1 as a susceptibility locus for Hirschsprung's disease

榮譽獎勵：

1.獲遼寧省跨世紀人才稱號。

2. 2021 常見小兒先天畸形早期診治關鍵技術與轉化應用，遼寧省科技進步一等獎，遼寧省人民政府，袁正偉等。

3.2021，常見嚴重出生缺陷的早期診斷與治療，中國醫(yī)院協(xié)會醫(yī)院科技創(chuàng)新三等獎，中國醫(yī)院協(xié)會，袁正偉等。

4.先天性肛門直腸畸形基礎與臨床研究，***; 袁正偉; 李龍; 白玉作; 張志波; 李正; 王練英; 王常林; 王偉; 賈慧敏，國務院國家獎勵辦, 科技進步, 國家二等獎, 2008.

5.先天性肛門直腸畸形基礎與臨床研究，***; 袁正偉; 張志波; 白玉作; 李龍; 王練英; 王常林; 鄭鳳春; 王偉; 曹德琴，遼寧省人民政府, 科技進步, 省部一等獎, 2006.

我院成功舉辦全國小兒外科肛腸疾病專題研討會

金秋十月，秋高氣爽。由中華醫(yī)學會小兒外科分會主辦、我院小兒外科承辦的中華小兒外科學會小兒肛腸疾病專題研討會10月15-17日在古城西安錦苑富潤大飯店隆重召開，全國多名小兒外科知名專家出席會議。

本次會議是中華醫(yī)學會小兒外科分會肛腸組換屆以來首次會議。應中華醫(yī)學會小兒外科分會肛腸組副組長、我院副院長、小兒外科博士生導師高亞教授邀請，中華醫(yī)學會小兒外科分會肛腸組組長、中國醫(yī)科大學附屬盛京醫(yī)院王維林教授，肛腸組副組長、解放軍總醫(yī)院劉洲祿教授、湖南省兒童醫(yī)院周小漁教授及肛腸組成員、重慶醫(yī)科大學附屬兒童醫(yī)院周德凱教授、首都醫(yī)科大學附屬北京兒童醫(yī)院陳亞軍教授、廣州市兒童醫(yī)院朱德力教授、中國醫(yī)科大學附屬盛京醫(yī)院袁正偉教授等十二名國內(nèi)知名小兒外科專家齊聚西安，共謀小兒外科肛腸疾病診治新發(fā)展。我院小兒外科主任徐泉教授、張憲生教授、吳宣林副教授以及小兒外科多名醫(yī)師參加會議。會議旨在研究討論小兒巨結腸同源病、小兒便失禁、排便障礙性生物反饋訓練、小兒功能性便秘的診斷標準及治療流程方案。會議由高亞教授主持，他首先代表我院對各位專家在百忙之中來到西安參會表示熱烈的歡迎，同時高度評價了本次研討會對小兒肛腸疾病的重大意義。會議期間，組長王維林教授全面闡述了上述疾病的國內(nèi)外研究進展情況，并提出了指導性意見。各位與會代表積極發(fā)言，分別匯報了各自所做的工作。高亞教授就先天性巨結腸有關內(nèi)容做了專題報告，會議討論氣氛熱烈，達到了會議的預期目的。

會議結束時，各位專家對我院成功舉辦此次研討會表示熱烈祝賀，并對會議期間會務組熱情周到的接待服務表示衷心的感謝，同時也預祝我院未來的發(fā)展更加美好。

來源：西安交通大學第二附屬醫(yī)院 2010-10-19